Hubungan Antara Faktor Demografi dan Penyakit Komorbid Terhadap Gangguan Penciuman dan Pengecapan Pada Penderita Covid-19 Yang Berobat Jalan di Poli Covid Rsup Haji Adam Malik Medan
Abstract
Pandemi Coronavirus Disease 2019 (COVID-19) masih terus berlangsung hingga saat ini. Pandemi ini disebabkan oleh infeksi Severe Acute Respiratory Syndrome – Coronavirus -2 (SARS-CoV-2). Infeksi SARS-CoV-2 dapat menimbulkan gangguan penciuman dan pengecapan. Kejadian gangguan penciuman ini diketahui lebih banyak dialami oleh pasien rawat jalan dibandingkan rawat inap. Durasi pemulihan dari gangguan pengecapan dan penciuman bervariasi antar penelitian.Untuk mengetahui hubungan usia, jenis kelamin dan komorbid terhadap durasi dari gangguan penciuman pengecapan pada penderita COVID-19 yang berobat jalan di Poli COVID-19 RSUP Haji Adam Malik Medan.penelitian ini menggunakan desain potong lintang (cross-sectional). Penelitian ini menggunakan data dari bulan Agustus-Desember 2021. Besar sampel pada penelitian sebanyak 40 subjek yang diambil dengan pendekatan consecutive sampling. Untuk data karakteristik demografi, gangguan penciuman dan pengecapan menggunakan rekam medis sedangkan untuk durasi penyembuhan dilakukan dengan wawancara melalui telepon.Mayoritas subjek pada penelitian ini adalah perempuan (57,5%), usia terbanyak dibawah 40 tahun (55%), lulusan SMA (57,5%), pekerjaan lainnya (32,5%), da nkomorbid terbanyak ialah hipertensi (12,5%). Gangguan penciuman dijumpai pada 65% subjek dengan durasi dibawah 15 hari pada 88,5% subjek sedangkan gangguan pengecapan dijumpai pada 55% subjek dengan durasi diatas 10 hari pada 54,5% subjek. Tidak didapatkan hubungan yang signifikan antara jenis kelamin, usia dan komorbid terhadap terjadinya gangguan penciuman, pengecapan serta durasi baik gangguan penciuman maupun pengecapan .Tidak ada hubungan antara usia, jenis kelamin dan komorbid terhadap durasi penyembuhan gangguan penciuman serta pengecapan.
Downloads
References
Abbas, T.G., Siddiqui, A.H., Zaidi, S.H.A., et al (2021). Anosmia and ageusia in patients with COVID-19. Pakistan Armed Forces Medical Journal, 71:S512-516. Doi:10.51253/pafmj.v1i1.7934
Al-Ani, R. M., & Acharya, D. (2020). Prevalence of Anosmia and Ageusia in Patients with COVID-19 at a Primary Health Center, Doha, Qatar. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 1–7. Advance online publication. https://doi.org/10.1007/s12070-020-02064-9
Al-Rawi, N. H., Sammouda, A. R., AlRahin, E. A., et al. (2022). Prevalence of Anosmia or Ageusia in Patients With COVID-19 Among United Arab Emirates Population. International dental journal, 72(2), 249–256. https://doi.org/10.1016/j.identj.2021.05.006
Algahtani, S. N., Alzarroug, A. F., Alghamdi, H. K., Algahtani, H. K., Alsywina, N. B., & Bin Abdulrahman, K. A. (2022). Investigation on the Factors Associated with the Persistence of Anosmia and Ageusia in Saudi COVID-19 Patients. International journal of environmental research and public health, 19(3), 1047. https://doi.org/10.3390/ijerph19031047
Bayrak, A. F., Karaca, B., & Özkul, Y. (2021). Could smell and taste dysfunction in COVID-19 patients be a sign of the clinical course of the disease?. The Egyptian Journal of Otolaryngology, 37(1), 106. https://doi.org/10.1186/s43163-021-00169-8
Biadsee, A., Dagan, O., Ormianer, Z., Kassem, F., Masarwa, S., & Biadsee, A. (2021). Eight-month follow-up of olfactory and gustatory dysfunctions in recovered COVID-19 patients. American journal of otolaryngology, 42(4), 103065. https://doi.org/10.1016/j.amjoto.2021.103065
Chary, E., Carsuzaa, F., Trijolet, J., Capitaine, A., Roncato-Saberan, M., & Fouet, K. et al. (2020). Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study. American Journal Of Rhinology & Allergy, 34(5), 686-693. doi: 10.1177/1945892420930954
Chen, N., Zhou, M., Dong, X., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London,England), 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7
Dahlan, S. (2014). Statistik Untuk Kedokteran dan Kesehatan Seri 1 : Deskriptif, Bivariat dan Multivariat Dilengkapi Aplikasi Menggunakan SPSS. 6th edition. Jakarta: Epidemiologi Indonesia
Duhri, A.P., Jabbar, R., Yunus, N. (2020). Karakteristik Pasien Konfirmasi COVID-19 di RSUD Lamaddukkelleng Kabupaten Wajo (Tinjauan Pasien Periode Maret-September 2020). Media Kesehatan Politeknik Kesehatan Makassar, 15(2), 319-326. https://doi.org/10.32382/medkes.v15i2.1789
Ejaz, H., Alsrhani, A., Zafar, A., et al. (2020). COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of infection and public health, 13(12), 1833–1839. https://doi.org/10.1016/j.jiph.2020.07.014
Fischer, M. E., Cruickshanks, K. J., Schubert, C. R., Pinto, A., Klein, R., Pankratz, N., Pankow, J. S., & Huang, G. H. (2013). Factors related to fungiform papillae density: the beaver dam offspring study. Chemical senses, 38(8), 669–677. https://doi.org/10.1093/chemse/bjt033
Galasso, V., Pons, V., Profeta, P., Becher, M., Brouard, S., & Foucault, M. (2020). Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries. Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27285–27291. https://doi.org/10.1073/pnas.2012520117
Griffith, D. M., Sharma, G., Holliday, C. S., et al. (2020). Men and COVID-19: A Biopsychosocial Approach to Understanding Sex Differences in Mortality and Recommendations for Practice and Policy Interventions. Preventing chronic disease, 17, E63. https://doi.org/10.5888/pcd17.200247
Klopfenstein, T., Zahra, H., Kadiane-Oussou, N. J., Lepiller, Q., Royer, P. Y., Toko, L., Gendrin, V., & Zayet, S. (2020). New loss of smell and taste: Uncommon symptoms in COVID-19 patients on Nord Franche-Comte cluster, France. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 100, 117–122. https://doi.org/10.1016/j.ijid.2020.08.012
Kosugi, E. M., Lavinsky, J., Romano, F. R., et al. (2020). Incomplete and late recovery of sudden olfactory dysfunction in COVID-19. Brazilian journal of otorhinolaryngology, 86(4), 490–496. https://doi.org/10.1016/j.bjorl.2020.05.001
Kusnik, A., Weiss, C., Neubauer, M., Huber, B., Gerigk, M., & Miethke, T. et al. (2021). Presence of gustatory and olfactory dysfunction in the time of the COVID-19 pandemic. BMC Infectious Diseases, 21(1). doi: 10.1186/s12879-021-06294-2
Lemeshow, S., Hosmer, D. W., Klar, J., & Lwanga, S. K. (1990). Adequacy of Sample Size in Health Studies. In John Wiley and Sons. John Wiley and Sons. https://doi.org/10.2307/2532527
Mutambudzi, M., Niedwiedz, C., Macdonald, E. B., et al. (2020). Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants. Occupational and environmental medicine, 78(5), 307–314. Advance online publication. https://doi.org/10.1136/oemed-2020-106731
Mutiawati, E., Fahriani, M., Mamada, S. S., et al. (2021). Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis. F1000Research, 10, 40. https://doi.org/10.12688/f1000research.28393.1
Nouchi, A., Chastang, J., Miyara, M., et al. (2021). Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 40(4), 691–697. https://doi.org/10.1007/s10096-020-04056-7
Paderno, A., Mattavelli, D., Rampinelli, V., et al. (2020). Olfactory and Gustatory Outcomes in COVID-19: A Prospective Evaluation in Nonhospitalized Subjects. Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(6), 1144–1149. https://doi.org/10.1177/0194599820939538
Ren, L. L., Wang, Y. M., Wu, Z. Q., Xiang, Z. C., Guo, L., Xu, T., Jiang, Y. Z., Xiong, Y., Li, Y. J., Li, X. W., Li, H., Fan, G. H., Gu, X. Y., Xiao, Y., Gao, H., Xu, J. Y., Yang, F., Wang, X. M., Wu, C., Chen, L., … Wang, J. W. (2020). Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chinese medical journal, 133(9), 1015–1024. https://doi.org/10.1097/CM9.0000000000000722
Sanli, D., Altundag, A., Kandemirli, S. G., et al. (2021). Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia. American journal of otolaryngology, 42(1), 102796. https://doi.org/10.1016/j.amjoto.2020.102796
Satuan Tugas Penanganan COVID-19 Indonesia. (2021).
Singer-Cornelius, T., Cornelius, J., Oberle, M., Metternich, F. U., & Brockmeier, S. J. (2021). Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 278(9), 3325–3332. https://doi.org/10.1007/s00405-020-06590-8
Tan, B., Han, R., Zhao, J., Tan, N., Quah, E., Tan, C., Chan, Y., Teo, N., Charn, T., See, A., Xu, S., Chapurin, N., Chandra, R., Chowdhury, N., Butowt, R., von Bartheld, C., Kumar, B., Hopkins, C. and Toh, S., (2022). Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves. BMJ, p.e069503.
Tenforde, M. W., Billig Rose, E., Lindsell, C. J., et al. CDC COVID-19 Response Team (2020). Characteristics of Adult Outpatients and Inpatients with COVID-19 - 11 Academic Medical Centers, United States, March-May (2020). MMWR. Morbidity and mortality weekly report, 69(26), 841–846. https://doi.org/10.15585/mmwr.mm6926e3
Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020). The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(1), 3–11. https://doi.org/10.1177/0194599820926473
aVaira, L. A., Lechien, J. R., Salzano, G., Salzano, F. A., Maglitto, F., Saussez, S., & De Riu, G. (2020). Gustatory Dysfunction: A Highly Specific and Smell-Independent Symptom of COVID-19. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 1–3. Advance online publication. https://doi.org/10.1007/s12070-020-02182-4
bVaira, L.A., Salzano, G., Fois, A.F., Piombino, P., Riu De G (2020) Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol 10:1103–1104
cVaira, L. A., Hopkins, C., Salzano, G., et al. (2020). Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head & neck, 42(7), 1560–1569. https://doi.org/10.1002/hed.26269
Wang, D., Hu, B., Hu, C., et al. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan China. JAMA, 323(11), 1061–1069. https://doi.org/10.1001/jama.2020.1585
Whitcroft, K. L., & Hummel, T. (2020). Olfactory Dysfunction in COVID-19:
Yan, C. H., Faraji, F., Prajapati, D. P., Boone, C. E., & DeConde, A. S. (2020). Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. International forum of allergy & rhinology, 10(7), 806–813. https://doi.org/10.1002/alr.22579
Copyright (c) 2023 Coryza Gabrie Tan, Andrina Y. M. Rambe, Siti Hajar Haryuna
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.