Hubungan Komorbid Diabetes Melitus dengan Tingkat Keparahan dan Mortalitas Pasien COVID-19 di RS Husada Periode Januari-Desember 2020
Abstract
COVID-19 masih menjadi perhatian utama dalam penanganan masalah kesehatan di berbagai negara, termasuk Indonesia. Keberadaan komorbiditas juga turut berperan dalam perjalanan penyakit ini, Salah satunya komorbid diabetes melitus. Selain itu, peningkatan penderita diabetes melitus semakin meningkatkan kewaspadaan akan hubungannya dengan tingkat keparahan dan mortalitas pasien COVID-19. Hal ini menjadikannya penting untuk diketahui peranan komorbid diabetes melitus dengan kondisi penyakit COVID-19. Penelitian ini dilakukan dengan tujuan untuk mengetahui hubungan antara komorbid diabetes melitus dengan tingkat keparahan dan mortalitas pasien COVID-19. Studi ini merupakan studi analitik observasional dengan desain penelitian cross-sectional, yang dilaksanakan pada 418 pasien COVID-19 yang dirawat di RS Husada Januari-Desember 2020. Hasil penelitian mendapatkan mayoritas pasien COVID-19 dengan komorbid diabetes melitus mengalami tingkat keparahan berat/kritis (61,4%) dan keberadaan komorbid diabetes melitus meningkatkan kejadian kematian pada pasien COVID-19 sebesar 5,9 kali (p-value <0,05). Penelitian ini juga menemukan bahwa usia, penggunaan terapi insulin, dan keberadaan komorbiditas lain juga berperan dalam perburukan kondisi COVID-19.
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References
Arianggara, A. W., Margiyanti, N. J., Sari, D. P., Tarigan, R. A., & Handayani, T. Y. (2022). Optimalisasi kelas ibu hamil sebagai upaya peningkatan kesehatan pada masa kehamilan dan persiapan persalinan. Dedikasi Sains Dan Teknologi (DST), 2(1), 34–38.
Busetto, L., Bettini, S., Fabris, R., Serra, R., Dal Pra, C., Maffei, P., Rossato, M., Fioretto, P., & Vettor, R. (2020). Obesity and COVIDâ€19: an Italian snapshot. Obesity, 28(9), 1600–1605. https://doi.org/10.1002/oby.22918
Celik, S., Bal, M. D., & Kelleci, M. (2023). Comparison of sexual functions in women with and without type 1 diabetes. Revista Da Associação Médica Brasileira, 69, 216–221. https://doi.org/10.1590/1806-9282.20220293
Chudasama, Y. V, Zaccardi, F., Gillies, C. L., Razieh, C., Yates, T., Kloecker, D. E., Rowlands, A. V, Davies, M. J., Islam, N., & Seidu, S. (2021). Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the UK. BMC Infectious Diseases, 21(1), 1–12. https://doi.org/10.1186/s12879-021-06600-y
Ejaz, H., Alsrhani, A., Zafar, A., Javed, H., Junaid, K., Abdalla, A. E., Abosalif, K. O. A., Ahmed, Z., & Younas, S. (2020). COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of Infection and Public Health, 13(12), 1833–1839. https://doi.org/10.1016/j.jiph.2020.07.014
Guan, W., Liang, W., Zhao, Y., Liang, H., Chen, Z., Li, Y., Liu, X., Chen, R., Tang, C., & Wang, T. (2020). Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal, 55(5). https://doi.org/10.1183/13993003.00547-2020
Liang, X., Xu, J., Xiao, W., Shi, L., & Yang, H. (2021). The association of diabetes with COVID-19 disease severity: evidence from adjusted effect estimates. Hormones, 20, 409–414. https://doi.org/10.1007/s42000-020-00259-x
Liu, Y., Mao, B., Liang, S., Yang, J.-W., Lu, H.-W., Chai, Y.-H., Wang, L., Zhang, L., Li, Q.-H., & Zhao, L. (2020). Association between age and clinical characteristics and outcomes of COVID-19. European Respiratory Journal, 55(5). https://doi.org/10.1183/13993003.01112-2020
Malik, J. A., Ahmed, S., Shinde, M., Al-Marmash, M. H. S., Alghamdi, S., Hussain, A., & Anwar, S. (2022). The impact of COVID-19 on the comorbidities: a review of recent updates for combating it. Saudi Journal of Biological Sciences. https://doi.org/10.1016/j.sjbs.2022.02.006
Pontoh, R. S., Toharudin, T., Ruchjana, B. N., Gumelar, F., Putri, F. A., Agisya, M. N., & Caraka, R. E. (2022). Jakarta pandemic to endemic transition: forecasting COVID-19 using NNAR and LSTM. Applied Sciences, 12(12), 5771.
Riahi, S., Sombra, L. R. S., Lo, K. B., Chacko, S. R., Neto, A. G. M., Azmaiparashvili, Z., Patarroyo-Aponte, G., Rangaswami, J., & Anastasopoulou, C. (2021). Insulin use, diabetes control, and outcomes in patients with COVID-19. Endocrine Research, 46(2), 45–50. https://doi.org/10.1080/07435800.2020.1856865
Sarkar, S., Das, D., Wann, S. B., Kalita, J., & Manna, P. (2021). Is diabetes mellitus a wrongdoer to COVID-19 severity? Diabetes Research and Clinical Practice, 178, 108936. https://doi.org/10.1016/j.diabres.2021.108936
Seiglie, J., Platt, J., Cromer, S. J., Bunda, B., Foulkes, A. S., Bassett, I. V, Hsu, J., Meigs, J. B., Leong, A., & Putman, M. S. (2020). Diabetes as a risk factor for poor early outcomes in patients hospitalized with COVID-19. Diabetes Care, 43(12), 2938–2944. https://doi.org/10.2337/dc20-1506
Siahaan, A., Utomo, B., Yuliana, R., Makful, M., Risma, R., & Salama, N. (2021). Distribusi spasial Covid-19 di DKI Jakarta, Indonesia (Januari 2021-Oktober 2021). Journal of Health Epidemiology and Communicable Diseases, 7(2), 84–92. https://doi.org/10.22435/jhecds.v7i2.5552
Sun, B., Huang, S., & Zhou, J. (2021). Perspectives of antidiabetic drugs in diabetes with coronavirus infections. Frontiers in Pharmacology, 11, 592439. https://doi.org/10.3389/fphar.2020.592439
Varikasuvu, S. R., Dutt, N., Thangappazham, B., & Varshney, S. (2021). Diabetes and COVID-19: a pooled analysis related to disease severity and mortality. Primary Care Diabetes, 15(1), 24–27. https://doi.org/10.1016/j.pcd.2020.08.015
Zaki, I. A., Zulkifly, H. H., Mansor, N. F., Lee, C. K., Eng, K. S., Ravi, T., & Pathmanathan, M. (2022). Mortality Among COVID-19 Patients in the Intensive Care Unit (ICU): A Single-Centre Study from a Malaysian Perspective. International Journal of Infectious Diseases, 116, S34. https://doi.org/10.1016/j.ijid.2021.12.081
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