Dampak Penggunaan Antibiotik Selama Pandemi Covid-19 Terhadap Resistensi Antibiotik: Literature Review
Keywords:
covid-19, antibiotik, resistensi
Abstract
Pandemi Covid-19 yang terjadi di seluruh dunia memiliki dampak yang signifikan pada sistem kesehatan masyarakat. Peningkatan dan perubahan pola penggunaan antibiotik selama pandemik Covid-19 berpotensi menimbulkan masalah baru. Penggunaan antibiotik yang berlebih dan tidak tepat pada era pandemi Covid-19 menjadi ancaman global terhadap meningkatnya kejadian resisten antibiotik dan berdampak pada peningkatan morbiditas, mortalitas, dan biaya kesehatan. Penelitian ini bertujuan untuk menganalisis dampak penggunaan antibiotik selama pandemi covid-19 terhadap resistensi antibiotik. Penelitian dilakukan dengan menelaah artikel penelitian dari tahun 2020 hingga 2023, dengan menggunakan metode Literature Review dan menghasilkan sepuluh artikel yang relevan dengan tujuan penelitian. Dari hasil telaah artikel didapatkan kesimpulan bahwa terdapat peningkatan dan perubahan pola penggunaan antibiotik selama pandemi Covid-19 serta peningkatan resistensi antibiotik yang signifikan. Upaya yang komprehensif diperlukan untuk mengatasi masalah ini, termasuk kolaborasi antara tenaga kesehatan, pemerintah, dan masyarakat dalam mempromosikan penggunaan antibiotik yang rasional dan pengendalian infeksi yang efektif.
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References
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Al-Azzam, S., Mhaidat, N. M., Banat, H. A., Alfaour, M., Ahmad, D. S., Muller, A., Al-Nuseirat, A., Lattyak, E. A., Conway, B. R., & Aldeyab, M. A. (2021). An Assessment of the Impact of Coronavirus Disease (COVID-19) Pandemic on National Antimicrobial Consumption in Jordan. Antibiotics, 10(6), 690. https://doi.org/10.3390/antibiotics10060690
Allegranzi, B., Nejad, S. B., Combescure, C., Graafmans, W., Attar, H., Donaldson, L., & Pittet, D. (2011). Burden of endemic health-care-associated infection in developing countries: Systematic review and meta-analysis. The Lancet, 377(9761), 228–241. https://doi.org/10.1016/S0140-6736(10)61458-4
Antimicrobial Resistance Collaborators. (2022). Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet (London, England), 399(10325), 629–655. https://doi.org/10.1016/S0140-6736(21)02724-0
Garg, S. K. (2021). Antibiotic misuse during COVID-19 Pandemic: A Recipe for Disaster. Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine, 25(6), 617–619. https://doi.org/10.5005/jp-journals-10071-23862
Gasperini, B., Cherubini, A., Lucarelli, M., Espinosa, E., & Prospero, E. (2021). Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards. Antibiotics, 10(1), 95. https://doi.org/10.3390/antibiotics10010095
Granata, G., Schiavone, F., Pipitone, G., Taglietti, F., Petrosillo, N. (2022). Antibiotics Use in COVID-19 Patients: A Systematic Literature Review. Journal of Clinical Medicine, 11(23), 7207. https://doi.org/10.3390/jcm11237207
Holmes, A. H., Moore, L. S. P., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., Guerin, P. J., & Piddock, L. J. V. (2016). Understanding the mechanisms and drivers of antimicrobial resistance. The Lancet, 387(10014), 176–187. https://doi.org/10.1016/S0140-6736(15)00473-0
Kharshid, A., Saadh, M., Taani, R., Aldmour, D., & Dayyih, W. (2021). Antibiotic Misuse During COVID-19 Pandemic: Review Study. http://pharmacologyonline.silae.it
Khor, W. P., Olaoye, O., D’Arcy, N., Krockow, E. M., Elshenawy, R. A., Rutter, V., & Ashiru-Oredope, D. (2020). The Need for Ongoing Antimicrobial Stewardship during the COVID-19 Pandemic and Actionable Recommendations. Antibiotics, 9(12), 904. https://doi.org/10.3390/antibiotics9120904
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., Greko, C., So, A. D., Bigdeli, M., Tomson, G., Woodhouse, W., Ombaka, E., Peralta, A. Q., Qamar, F. N., Mir, F., … Cars, O. (2013). Antibiotic resistance—The need for global solutions. The Lancet Infectious Diseases, 13(12), 1057–1098. https://doi.org/10.1016/S1473-3099(13)70318-9
Lingas, E. C. (2022). Empiric Antibiotics in COVID 19: A Narrative Review. Cureus, 14(6), e25596. https://doi.org/10.7759/cureus.25596
Mustafa, Z. U., Khan, A. H., Harun, S. N., Salman, M., Godman, B. (2023). Antibiotic Overprescribing among Neonates and Children Hospitalized with COVID-19 in Pakistan and the Implications. Antibiotics, 12(4), 646. https://doi.org/10.3390/antibiotics12040646
Nandi, A., Pecetta, S., & Bloom, D. E. (2023). Global antibiotic use during the COVID-19 pandemic: Analysis of pharmaceutical sales data from 71 countries, 2020–2022. EClinicalMedicine, 57, 101848. https://doi.org/10.1016/j.eclinm.2023.101848
Ng, Q. X., Ong, N. Y., Lee, D. Y. X., Yau, C. E., Lim, Y. L., Kwa, A. L. H., & Tan, B. H. (2023). Trends in Pseudomonas aeruginosa (P. aeruginosa) Bacteremia during the COVID-19 Pandemic: A Systematic Review. Antibiotics, 12(2), 409. https://doi.org/10.3390/antibiotics12020409
Nori, P., Cowman, K., Chen, V., Bartash, R., Szymczak, W., Madaline, T., Punjabi Katiyar, C., Jain, R., Aldrich, M., Weston, G., Gialanella, P., Corpuz, M., Gendlina, I., & Guo, Y. (2020). Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge. Infection Control and Hospital Epidemiology, 1–5. https://doi.org/10.1017/ice.2020.368
Rawson, T. M., Moore, L. S. P., Zhu, N., Ranganathan, N., Skolimowska, K., Gilchrist, M., Satta, G., Cooke, G., & Holmes, A. (2020). Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 71(9), 2459–2468. https://doi.org/10.1093/cid/ciaa530
Saleem, Z., Haseeb, A., , Godman, B., Batool, N., Altaf, U., Ahsan, U., Khan, F. U., Mustafa, Z. U., Nadeem, M. U., Farrukh, M. J., Mugheera, M., Rehman, I. U., Khan, A. F., Saeed, H. (2023). Point Prevalence Survey of Antimicrobial Use during the COVID-19 Pandemic among Different Hospitals in Pakistan: Findings and Implications. Antibiotics, 12(1), 70. https://doi.org/10.3390/antibiotics12010070
Smith, D. R. M., Shirreff, G., Temime, L., & Opatowski, L. (2023). Collateral impacts of pandemic COVID-19 drive the nosocomial spread of antibiotic resistance: A modelling study. PLoS Medicine, 20(6), e1004240. https://doi.org/10.1371/journal.pmed.1004240
Stone, P. W. (2009). Economic burden of healthcare-associated infections: An American perspective. Expert Review of Pharmacoeconomics & Outcomes Research, 9(5), 417–422. https://doi.org/10.1586/erp.09.53
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., Ouellette, M., Outterson, K., Patel, J., Cavaleri, M., Cox, E. M., Houchens, C. R., Grayson, M. L., Hansen, P., Singh, N., … Zorzet, A. (2018). Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet Infectious Diseases, 18(3), 318–327. https://doi.org/10.1016/S1473-3099(17)30753-3
Taulant, M., Marija, G., Jelena, M., Sanne, V., Julia, B., Wichor, B., Rajiv, C., & Franco, O. H. (2020). A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. European Journal of Epidemiology, 35(1), 49–60. https://doi.org/10.1007/s10654-019-00576-5
Toc, D. A., Botan, A., Botescu, A. M. C., Brata, V. D., Colosi, I. A., Costache, C., & Junie, L. M. (2023). A Tale of Two Pandemics: Antimicrobial Resistance Patterns of Enterococcus spp. in COVID-19 Era. Antibiotics, 12(2), 312. https://doi.org/10.3390/antibiotics12020312
WHO Coronavirus (COVID-19) Dashboard. (2023). https://covid19.who.int
Zhu, B., Zhao, X., Li, Y., Wang, N., Lambert, H., Yan, F., Jiang, Q., Fu, C. (2022). Impact of the COVID-19 Outbreak on the Antibiotic Use Patterns among a Rural Community Population in Eastern China. Antibiotics, 11(11), 1544. https://doi.org/10.3390/antibiotics11111544
Published
2022-10-20
Section
Original Articles
Copyright (c) 2022 Anggraina Widiyanti
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
