Langerhans Cell Histiocytosis in Child Temporal Bone: A Case Report
Abstract
Langerhans Cell Histiocytosis (LCH) is one of the rare disease with atypical clinical manifestations. LCH must be watched out for and considered a differential diagnosis of the other otolaryngology diseases. A 2-years-10-months old boy with a crusted lump in the right ear canal accompanied by a lump behind the right ear that is expanding, bleeding for 3 months, and the patient experience loss of weight. Examination of the ear found a black mass covered with crusts with a firm, fixed consistency, filling the lateral one-third of the right external acoustic canal to the right auricle concha. A solid mass was obtained from the lateral one-third of the right external acoustic canal on a head CT scan, medially obliterating the external acoustic canal to the right internal acoustic canal. FNAB found nonspecific inflammation. Performed mass excision surgery and anatomical pathology examination. The patient was referred to the pediatric haemato-oncology division and underwent chemotherapy. Langerhans cell Histiocytosis in the temporal bone is a rare disease with atypical clinical manifestations, so it should be considered as one of the differential diagnoses if a mass is found in the external acoustic canal.
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References
Kim H, Kim Y-J, Shin J, MIN S, Kang SH, Suh JK, et al. Analysis of the Incidence and Diagnostic Pattern of Langerhans Cell Histiocytosis from the Population-Wide Healthcare Database in Korea. Blood. 2019;134(Supplement_1):4866. https://doi.org/10.1182/blood-2019-131531
Sterlich, K. , Minkov, M. . Childhood Langerhans Cell Histiocytosis: Epidemiology, Clinical Presentations, Prognostic Factors, and Therapeutic Approaches. In: Valarmathi, M. T. , editor. Rare Diseases - Diagnostic and Therapeutic Odyssey [Internet]. London: IntechOpen; 2021 [cited 2022 Oct 03]. Available from: https://www.intechopen.com/chapters/75678 doi: 10.5772/intechopen.96543
Saha KL, Dey BP, Joarder MAH, Haque MA, Bhowmik B. Bilateral Langerhans Cells Histiocytosis in the Temporal Bone: A case report. Bangladesh J Otorhinolaryngol. 2020;26(1):68–72. https://doi.org/10.3329/bjo.v26i1.47956
Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, et al. Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer. 2013;60(2):175–84. https://doi.org/10.1002/pbc.24367
Mayer S, Raggio BS, Master A, Lygizos N. Langerhans cell histiocytosis of the temporal bone. Ochsner J. 2020;20(3):315–8. https://doi.org/10.31486/toj.19.0032
Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Langerhans cell histiocytosis in children - A disease with many faces. Recent advances in pathogenesis, diagnostic examinations, and treatment. Postepy Dermatol Alergol. 2018;35(1):6–17. https://doi.org/10.5114/pdia.2017.67095
Brown CW, Jarvis JG, Letts M, Carpenter B. Treatment and outcome of vertebral Langerhans cell histiocytosis at the Children’s Hospital of Eastern Ontario. Can J Surg. 2005;48:230–6.
Kumar N, Sayed S, Vinayak S. Diagnosis of Langerhans Cell Histiocytosis on Fine Needle Aspiration Cytology: A Case Report and Review of the Cytology Literature. Pathology Res Int. 2011;2011(6):439518. https://doi.org/10.4061/2011/439518
Allen CE, Ladisch S, McClain KL. How I treat Langerhans cell histiocytosis. Blood. 2015;126(1):26–35. https://doi.org/10.1182/blood-2014-12-569301
Allen CE, Li L, Peters TL, Leung HE, Yu A, Man T-K, et al. Cell-Specific Gene Expression in Langerhans Cell Histiocytosis Lesions Reveals a Distinct Profile Compared with Epidermal Langerhans Cells. J Immunol. 2010;184(8):4557–67. https://doi.org/10.4049/jimmunol.0902336
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