Pengembangan Bahan Alam Dari Siput Gonggong (Laevistrombus Sp.) Untuk Penyembuhan Luka: Tinjauan Histologis
Keywords:
Laevistrombus sp, penyembuhan luka, senyawa bioaktif, antiinflamasi, histologi
Abstract
Penyembuhan luka merupakan proses biologis kompleks yang melibatkan fase inflamasi, proliferasi, dan remodeling jaringan. Pemanfaatan bahan alami dari laut, seperti siput gonggong (Laevistrombus sp.), menawarkan potensi besar sebagai agen penyembuh luka karena kandungan senyawa bioaktifnya yang memiliki aktivitas antimikroba, antiinflamasi, dan antioksidan. Penelitian ini bertujuan untuk meninjau potensi ekstrak siput gonggong dalam mempercepat penyembuhan luka melalui analisis terhadap kandungan bioaktif, mekanisme kerja, dan bukti histologis. Kajian dilakukan secara sistematis terhadap literatur dari PubMed, ScienceDirect, Google Scholar, dan Scopus dalam lima tahun terakhir hingga April 2025, dengan fokus pada aktivitas biologis moluska laut dan aplikasinya pada regenerasi jaringan kulit. Hasil tinjauan menunjukkan bahwa siput gonggong mengandung protein histon H2A, peptida antimikroba (AMPs), flavonoid, alkaloid, dan saponin yang berperan dalam menekan sitokin proinflamasi (TNF-?, IL-6), meningkatkan sitokin antiinflamasi (IL-10), serta menstimulasi proliferasi fibroblas, angiogenesis, dan sintesis kolagen melalui jalur NF-?B, PPAR-?, dan TGF-?/Smad. Secara histologis, senyawa ini mempercepat reepitelisasi dan meningkatkan deposisi kolagen pada jaringan luka. Dengan demikian, ekstrak siput gonggong memiliki potensi besar sebagai bahan dasar alami untuk pengembangan produk dermatologis dan farmasi yang aman, efektif, serta berkelanjutan.
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References
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Sila A, Bougatef A. Antioxidant peptides from marine by-products: Isolation, identification and application in food systems. A review. Vol. 21, Journal of Functional Foods. Elsevier Ltd; 2016. p. 10–26.
Trinh XT, Long N Van, Van Anh LT, Nga PT, Giang NN, Chien PN, et al. A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective. Vol. 23, International Journal of Molecular Sciences. MDPI; 2022.
Van De Vyver M, Boodhoo K, Frazier T, Hamel K, Kopcewicz M, Levi B, et al. Histology Scoring System for Murine Cutaneous Wounds. Stem Cells Dev. 2021 Dec 1;30(23):1141–52.
Viruly L, Andarwulan N, Suhartono MT, Nurilmala M. Protein profiles and DNA isolation of hemolymph gonggong snail (Strombus sp.) from Bintan. IOP Conf Ser Earth Environ Sci [Internet]. 2019 May 1 [cited 2025 Mar 15];278(1):012078. Available from: https://iopscience.iop.org/article/10.1088/1755-1315/278/1/012078
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Wilkinson HN, Hardman MJ. Wound healing: Cellular mechanisms and pathological outcomes. Advances in Surgical and Medical Specialties. 2023 Jun 23;341–70.
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Yunisa Friscia Yusri, Suhaera S, Suci Fitriani Sammulia, Harlyanti Muthma’innah Mashar, Doni Roga Septianus Siregar. Uji Aktivitas Antibakteri Ekstrak Etanol Siput Gonggong (Strombus Turturella) Terhadap Bakteri Pseudomonas Aeroginosa dan Staphylococcus Aureus. INSOLOGI: Jurnal Sains dan Teknologi. 2023 Jun 28;2(3):599–608.
Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, et al. A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect. Drug Des Devel Ther. 2019;13:3269–80.
Zulkefli N, Che Zahari CNM, Sayuti NH, Kamarudin AA, Saad N, Hamezah HS, et al. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. Vol. 24, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2023.
Cialdai F, Risaliti C, Monici M. Role of fibroblasts in wound healing and tissue remodeling on Earth and in space. Front Bioeng Biotechnol. 2022 Oct 4;10:958381.
Cioce A, Cavani A, Cattani C, Scopelliti F. Role of the Skin Immune System in Wound Healing. Cells [Internet]. 2024 Apr 1 [cited 2024 May 19];13(7):624. Available from: https://www.mdpi.com/2073-4409/13/7/624/htm
Comino-Sanz IM, López-Franco MD, Castro B, Pancorbo-Hidalgo PL. The role of antioxidants on wound healing: A review of the current evidence. J Clin Med. 2021 Aug 2;10(16).
Criollo-Mendoza MS, Contreras-Angulo LA, Leyva-López N, Gutiérrez-Grijalva EP, Jiménez-Ortega LA, Heredia JB. Wound Healing Properties of Natural Products: Mechanisms of Action. Molecules 2023, Vol 28, Page 598 [Internet]. 2023 Jan 6 [cited 2025 Jul 26];28(2):598. Available from: https://www.mdpi.com/1420-3049/28/2/598/htm
Eroschenko VP. Sistem Integumen. In: Atlas Histologi dengan Korelasi Fungsional. 13th ed. Jakarta: EGC; 2022. p. 316–36.
Fontana A, Gallo C, Cutolo EA, Campitiello R, Caferri R, Flavio Pagliuca V, et al. Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia. Marine Drugs 2024, Vol 22, Page 304 [Internet]. 2024 Jun 28 [cited 2024 Aug 29];22(7):304. Available from: https://www.mdpi.com/1660-3397/22/7/304/htm
Geahchan S, Baharlouei P, Rahman MA. Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration. Vol. 20, Marine Drugs. MDPI; 2022.
Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP. Wound healing - A literature review. An Bras Dermatol [Internet]. 2016 Sep 1 [cited 2024 Apr 3];91(5):614. Available from: /pmc/articles/PMC5087220/
Gupta A, Kumar P. Assessment of the histological state of the healing wound. Plast Aesthet Res. 2015;2(5):239.
Gushiken LFS, Beserra FP, Bastos JK, Jackson CJ, Pellizzon CH. Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. Life 2021, Vol 11, Page 665 [Internet]. 2021 Jul 7 [cited 2024 Apr 17];11(7):665. Available from: https://www.mdpi.com/2075-1729/11/7/665/htm
Ibrahim N ‘Izzah, Wong SK, Mohamed IN, Mohamed N, Chin KY, Ima-Nirwana S, et al. Wound healing properties of selected natural products. Vol. 15, International Journal of Environmental Research and Public Health. MDPI AG; 2018.
Krzyszczyk P, Schloss R, Palmer A, Berthiaume F. The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Vol. 9, Frontiers in Physiology. Frontiers Media S.A.; 2018.
kulsum D. UJI AKTIVITAS LUKA INSISI DENGAN EKSTRAK ETANOL 70% LIDAH BUAYA (Aloe vera L) TERHADAP PROSES PENYEMBUHAN LUKA PADA MENCIT PUTIH JANTAN (Mus musculus L.) INCISION WOUND ACTIVITY TEST WITH 70% ETHANOL EXTRACT OF ALOE VERA AGAINST WOUND HEALING PROCESS IN MALE WHITE MICE (Mus musculus L.). Vol. 5, Indonesia Natural Research Pharmaceutical Journal. 2020.
Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Vol. 73, Cellular and Molecular Life Sciences. Birkhauser Verlag AG; 2016. p. 3861–85.
Larouche J, Sheoran S, Maruyama K, Martino MM. Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets. Adv Wound Care (New Rochelle) [Internet]. 2018 Jul 7 [cited 2024 Apr 17];7(7):209. Available from: /pmc/articles/PMC6032665/
Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and Biomarkers for Wound Healing. Plast Reconstr Surg [Internet]. 2016 [cited 2024 Mar 15];138(3):18S. Available from: /pmc/articles/PMC4998971/
McKnight G, Shah J, Hargest R. Physiology of the skin. In: Surgery (Oxford). Elsevier; 2022. p. 788–92.
Merrell JG, McLaughlin SW, Tie L, Laurencin CT, Chen AF, Nair LS. Curcumin-loaded poly(?-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1149–56.
Muzahar, Putra WKA, Zahra A, Viruly L. Pengaruh Pemberian Ovaprim dan Human Chorionic Gonadotropin (hCG) terhadap Pemijahan Siput Gonggong Laevistrombus turturella. Jurnal Ilmu dan Teknologi Kelautan Tropis. 2020 Dec 31;12(3):711–21.
Ngandjui YAT, Kereeditse TT, Kamika I, Madikizela LM, Msagati TAM. Nutraceutical and Medicinal Importance of Marine Molluscs. Vol. 22, Marine Drugs. Multidisciplinary Digital Publishing Institute (MDPI); 2024.
Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, et al. Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care (New Rochelle) [Internet]. 2014 Jul 7 [cited 2024 Apr 17];3(7):445. Available from: /pmc/articles/PMC4086220/
Plikus M V., Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science [Internet]. 2017 Feb 17 [cited 2024 Mar 15];355(6326):748–52. Available from: https://pubmed.ncbi.nlm.nih.gov/28059714/
Raziyeva K, Kim Y, Zharkinbekov Z, Kassymbek K, Jimi S, Saparov A. Immunology of Acute and Chronic Wound Healing. Biomolecules 2021, Vol 11, Page 700 [Internet]. 2021 May 8 [cited 2024 Aug 29];11(5):700. Available from: https://www.mdpi.com/2218-273X/11/5/700/htm
Sherwood L. Pertahanan Tubuh. In: Yesdelita N, editor. Fisiologi Manusia: dari Sel ke Sistem. Jakarta: EGC; 2018. p. 476–520.
Sila A, Bougatef A. Antioxidant peptides from marine by-products: Isolation, identification and application in food systems. A review. Vol. 21, Journal of Functional Foods. Elsevier Ltd; 2016. p. 10–26.
Trinh XT, Long N Van, Van Anh LT, Nga PT, Giang NN, Chien PN, et al. A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective. Vol. 23, International Journal of Molecular Sciences. MDPI; 2022.
Van De Vyver M, Boodhoo K, Frazier T, Hamel K, Kopcewicz M, Levi B, et al. Histology Scoring System for Murine Cutaneous Wounds. Stem Cells Dev. 2021 Dec 1;30(23):1141–52.
Viruly L, Andarwulan N, Suhartono MT, Nurilmala M. Protein profiles and DNA isolation of hemolymph gonggong snail (Strombus sp.) from Bintan. IOP Conf Ser Earth Environ Sci [Internet]. 2019 May 1 [cited 2025 Mar 15];278(1):012078. Available from: https://iopscience.iop.org/article/10.1088/1755-1315/278/1/012078
Viruly L, Andarwulan N, TSuhartono M, Nurilmala M, Teknologi Hasil Perikanan J, Ilmu Kelautan dan Perikanan F, et al. PENAPISAN SENYAWA BIOAKTIF PADA SIPUT LAUT GONGGONG (Laevistrombus turturella) ASAL BINTAN. 2020.
Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. Vol. 81, Journal of the Chinese Medical Association. Elsevier Ltd; 2018. p. 94–101.
Wang S, Fan L, Pan H, Li Y, Qiu Y, Lu Y. Antimicrobial peptides from marine animals: Sources, structures, mechanisms and the potential for drug development. Front Mar Sci. 2023 Jan 19;9:1112595.
Wang Z, Qi F, Luo H, Xu G, Wang D. Inflammatory Microenvironment of Skin Wounds. Front Immunol [Internet]. 2022 Mar 1 [cited 2024 Mar 20];13:789274. Available from: www.frontiersin.org
Wilkinson HN, Hardman MJ. Wound healing: Cellular mechanisms and pathological outcomes. Advances in Surgical and Medical Specialties. 2023 Jun 23;341–70.
Yoswaty D, Fakultas Perikanan dan Kelautan Universitas Riau Kampus Bina Widya Km Z. Analisis Antibakteri Ekstrak Etanol Siput Gonggong (Strombus canarium) terhadap Bakteri Patogen Antibacterial Analysis of the Ethanol Extract of Gonggong Snail (Strombus canarium ) against Pathogenic Bacteria. Jurnal Perikanan Universitas Gadjah Mada. 18(2).
Yunisa Friscia Yusri, Suhaera S, Suci Fitriani Sammulia, Harlyanti Muthma’innah Mashar, Doni Roga Septianus Siregar. Uji Aktivitas Antibakteri Ekstrak Etanol Siput Gonggong (Strombus Turturella) Terhadap Bakteri Pseudomonas Aeroginosa dan Staphylococcus Aureus. INSOLOGI: Jurnal Sains dan Teknologi. 2023 Jun 28;2(3):599–608.
Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, et al. A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect. Drug Des Devel Ther. 2019;13:3269–80.
Zulkefli N, Che Zahari CNM, Sayuti NH, Kamarudin AA, Saad N, Hamezah HS, et al. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. Vol. 24, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2023.
Published
2025-11-03
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