Pengaruh Pemberian Ekstrak Kulit Mangga Arum Manis (Mangifera Indica) Terhadap Kadar Gula Darah Tikus Wistar Jantan Obesitas yang Diinduksi HFD (High Fat Diet) dan Aloksan
Keywords:
mango peel extract, Mangifera indica, obesity, blood glucose levels, Wistar rats
Abstract
Obesity is a major risk factor for type 2 diabetes mellitus characterized by insulin resistance and hyperglycemia. Sweet arum mango (Mangifera indica) peel contains bioactive compounds with potential as natural antidiabetic and antioxidant agents. This study aimed to determine the effect of sweet arum mango peel extract on blood glucose levels, body weight, and uric acid levels in obese male Wistar rats induced by HFD (high fat diet) and alloxan. An experimental study with a pretest-posttest control group design used 24 male Wistar rats divided into 4 groups: positive control (Pioglitazone 3 mg) and three treatment groups with mango peel extract at doses of 30, 60, and 120 mg/kgBW. Obesity was induced by high-fat diet administration for 21 days and alloxan 150 mg/kgBW intraperitoneally, followed by extract administration for 14 days. Data were analyzed using ANOVA and post hoc Tukey HSD tests. Phytochemical screening revealed that the extract contained alkaloids, terpenoids, saponins, and steroids. Descriptively, blood glucose levels decreased from 442.05 80.80 mg/dL to 109.50 21.15 mg/dL, but this was not statistically significant between groups (p=0.673). Body weight changes also showed no significant differences (p=0.947). Uric acid levels showed significant differences between treatment groups (p=0.006), with the 120 mg/kgBW dose significantly different from the 30 mg/kgBW (p=0.008) and 60 mg/kgBB doses (p=0.042). Sweet arum mango peel extract demonstrates biological potential in affecting glucose and uric acid metabolism in obese rats, although effects on blood glucose levels and body weight were not statistically significant. Further research with longer duration and optimal dosage is needed to validate the extract's effectiveness.
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References
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Ayyun, K., Rosydah, Y. K. I., Atikah, N., & Arianti, S. P. (2023). Profil Studi Fitokimia Dan Aktivitas Farmakologi Buah Mangga (Mangifera Indica L.).
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Dachi, V. O. N., Arif Rayyan, T., Putri Utami, S., Mutia, R., Akbar, K., Esmaralda Lumbantobing, C. J., Kunardi, S., & Hendriani Djuang, M. (2022). Pengaruh variasi pemberian dosis aloksan terhadap angka kadar gula darah hewan coba. Jurnal Prima Medika Sains, 4(1). https://doi.org/10.34012/jpms.v4i1.2460
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Haam, J. H., Kim, B. T., Kim, E. M., Kwon, H., Kang, J. H., Park, J. H., Kim, K. K., Rhee, S. Y., Kim, Y. H., & Lee, K. Y. (2023). Diagnosis of Obesity: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity. Dalam Journal of Obesity and Metabolic Syndrome (Vol. 32, Nomor 2, hlm. 121–129). Korean Society for the Study of Obesity. https://doi.org/10.7570/jomes23031
Hadi, P., & Suniaprily, F. G. A. (2024). EMPOWERMENT AGRICULTURE: HILIRISASI AGROINDRUSTRI BUAH MANGGA.
Hairil, A. (2021). Pemberian Edukasi Mengenai Obesitas pada Remaja di Madrasah Aliyah Negeri 1 Indramayu. Dalam Community Engagement & Emergence Journal (Vol. 2). https://journal.yrpipku.com/index.php/ceej
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Ifmaily, Firla, A., & Fitriani, P. R. (2023). The Effect of Arumanis Mango Rind (Mangifera indica L) Extract as Antidiabetic in Rats Model. Jurnal Sains Farmasi & Klinis, 10(3), 256. https://doi.org/10.25077/jsfk.10.3.256-263.2023
Khair, Y., Asrini Safitri, K., Lestari Daeng Kanang, I., & Latief, S. (2023). Hubungan Obesitas Dengan Kadar Gula Darah pada Mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia. FAKUMI MEDICAL JOURNAL .
Li, K., Wang, Y., Liu, W., Zhang, C., Xi, Y., Zhou, Y., Li, H., & Liu, X. (2024). Structure–Activity Relationships and Changes in the Inhibition of Xanthine Oxidase by Polyphenols: A Review. Foods (MDPI), 13(15). https://doi.org/10.3390/foods13152365
Li, X., Yan, Z., Carlström, M., Tian, J., Zhang, X., Zhang, W., Wu, S., & Ye, F. (2020). Mangiferin ameliorates hyperuricemic nephropathy which is associated with downregulation of AQP2 and increased urinary uric acid excretion. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.00049
Luqyana T M, L. Z., & Husni, P. (2019). AKTIVITAS FARMAKOLOGI TANAMAN MANGGA (MANGIFERA INDICA L.): REVIEW.
Marcelin, G., Gautier, E. L., & Clément, K. (2022). Adipose Tissue Fibrosis in Obesity: Etiology and Challenges. Annual Review of Physiology, 18, 38. https://doi.org/10.1146/annurev-physiol-060721
MIchelle Mouri, A., & Badireddy Affiliations, M. (2023). Hyperglycemia. StatPearls Publishing.
Mistry, J., Biswas, M., Sarkar, S., & Ghosh, S. (2023). Antidiabetic activity of mango peel extract and mangiferin in alloxan-induced diabetic rats. Future Journal of Pharmaceutical Sciences, 9(1). https://doi.org/10.1186/s43094-023-00472-6
Mojkowska, A., Sobczak, K., Leoniuk, K., Henzler, M., & Jackowski, M. (2023). Medical or Common Knowledge? Knowledge of Medical Professionals on Obesity Diagnosis Criteria and Treatment. Obesity Facts, 16(3), 216–223. https://doi.org/10.1159/000529266
Nazira, S., Selvester Thadeus, M., & Hardini, N. (2020). UJI EFEKTIVITAS EKSTRAK BIJI KETUMBAR (CORIANDRUM SATIVUM L.) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS HIPERKOLESTEROLEMIA DIABETES. 4(1), 357–368. https://doi.org/10.24912/jmistkik.v4i2.8249
Noviyanty, Y., Ardelia, W., & Al Fatah. (2022). PENETAPAN KADAR SENYAWA FLAVONOID TOTAL DARI EKSTRAK ETANOL KULIT BUAH MANGGA ARUM MANIS (Mangifera Indica L. Var. Arum Manis) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Determination of Total Flavonoid Compounds from The Ethanol Extract of Sweet Arum Mango Fruit Leather with The Uv-Vis Spectrophotometry Method. Dalam Jurnal Sains Kesehatan (Vol. 29, Nomor 1).
Noviyanty, Y., Hepiyansori, & annis. (2022). Oceana Biomedicina Journal VARIASI KOSENTRASI EKSTRAK ETANOL KULIT BUAH MANGGA HARUM MANIS (Mangifera indica L var. arum manis) TERHADAP FORMULA SEDIAAN GEL HAND SANITIZER SEBAGAI BAKTERIOSTATIK Staphylococus Aureus.
Nurhidayati, N., Irawan, I. R., & Sudikno, S. (2022). HUBUNGAN OBESITAS DENGAN PROFIL LIPID PADA REMAJA DI INDONESIA. Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research), 45(1), 35–46. https://doi.org/10.22435/pgm.v45i1.6081
Paris J Hantzidiamantis, Ayoola O Awosika, & Sarah L Lappin. (2024). Physiology, glucose. StatPearls Publishing.
Preciado-Saldaña, A. M., Domínguez-Avila, J. A., Ayala-Zavala, J. F., Astiazaran-Garcia, H. F., Montiel-Herrera, M., Villegas-Ochoa, M. A., González-Aguilar, G. A., & Wall-Medrano, A. (2022). Mango “Ataulfo” Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats. Life (MDPI), 12(4). https://doi.org/10.3390/life12040532
Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M. G. (2021). Role of insulin in health and disease: An update. Dalam International Journal of Molecular Sciences (Vol. 22, Nomor 12). MDPI. https://doi.org/10.3390/ijms22126403
Rusmini Hetti, Fitriani Dita, Ulfa Ade Maria, & Ricki Gustiawan. (2021). STUDI LITERATUR: PENGARUH PEMBERIAN EKSTRAK DAUN BAYAM MERAH (Amaranthus tricolor L.) TERHADAP INDEKS LEE DAN MASSA LEMAK ABDOMINAL PADA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR JANTAN YANG DIBERI DIET TINGGI LEMAK. Jurnal Ilmu Kedokteran Dan Kesehatan.
Saputra, T., Naufal, H. S., Utomo, A. W., Widyastiti, N. S., Kurniawan, M. F., & Azizah, A. N. (2023). Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats. Medical Journal of Indonesia, 32(3), 157–160. https://doi.org/10.13181/mji.oa.236960
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Published
2025-10-27
Section
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Copyright (c) 2025 Oktari Rahmadani, Yohani Theresia, Tri Lidya Anggraini
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