Hubungan Kadar C-Reaktiv Protein (CRP) dengan Nilai Cycle Treshold (CT) pada Penderita Covid-19
Abstract
Latar Belakang: Infeksi COVID-19 disebabkan oleh virus corona, dengan gejala utama berupa gangguan pernapasan. Pemeriksaan diagnostik yang umum dilakukan yaitu rapid test antigen, rapid test antibodi, ELISA dan RT-PCR. Pemeriksaan baku emas untuk mendiagnosis COVID-19 adalah RT-PCR. Parameter lain yang disarankan adalah viral load yaitu nilai Cycle treshold. CRP merupakan salah satu parameter pemeriksaan penanda inflamasi pada kasus COVID-19. Kadar C-Reaktif Protein dapat digunakan untuk diagnosis awal pneumonia. Pasien dengan pneumonia berat terjadi peningkatan kadar C-Reaktif Protein yang tinggi. Tujuan penelitian ini untuk mengetahui korelasi nilai Cycle threshold dengan kadar C-Reaktif Protein, pada penderita COVID-19. Jenis penelitian yang dilakukan adalah kuantitatif non eksperimental korelasional, penelitian dilakukan di Laboratorium Rumah Sakit Charitas Hospital KM.7 Palembang pada bulan Mei s/d Juni 2020. Subjek penelitian adalah pasien rawat inap di Rumah Sakit Charitas Hospital KM.7 sebanyak 40 orang. Uji statistik yang digunakan uji korelasi pearson, hasil uji didapatkan nilai sig 0,494 (p > 0,05). Kesimpulan tidak terdapat hubungan antara nilai Cycle treshold dan kadar C-Reaktif Protein pada penderita COVID-19.
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Dergaa, I., Abubaker, M., Souissi, A., Mohammed, A. R., Varma, A., Musa, S., Al Naama, A., Mkaouer, B., & Ben Saad, H. (2022). Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value. Libyan Journal of Medicine, 17(1). https://doi.org/10.1080/19932820.2021.2010337
Elemam, N. M., Maghazachi, A. A., & Hannawi, S. (2021). COVID-19 infection and rheumatoid arthritis: mutual outburst cytokines and remedies. Current Medical Research and Opinion, 37(6), 929–938. https://doi.org/10.1080/03007995.2021.1906637
Erlina Burhan. (2020). Pedoman Tatalaksana Covid-19.
Herawati, N. (2020). Jenis-Jenis Metode Rapid-Test Untuk Deteksi Virus SARS-CoV-2.
Ingberg, E., Ahlstrand, E., Cajander, P., Löf, E., Sundqvist, M., Wegener, M., Lidén, M., & Cajander, S. (2022). RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19. Infectious Diseases, 54(6), 431–440. https://doi.org/10.1080/23744235.2022.2035428
Moneva-Sakelarieva, M. G., Kobakova, Y. A., Atanasov, P. Y., Obreshkova, D. P., Ivanova, S. A., & Stankova, E. K. (2021). COVID-19 – the challenge to treat a disease and not a positive RT-PCR test. Pharmacia, 68(1), 155–161. https://doi.org/10.3897/pharmacia.68.e61906
Nguyen T, B. D. dan W. A. (n.d.). Novel Coronavirus Disease (Covid-19): Paving the road for rapid detection andpoint of care diagnostic, Micromachines. 2020.
Ponti, G., Maccaferri, M., Ruini, C., Tomasi, A., & Ozben, T. (2020). Biomarkers associated with COVID-19 disease progression. Critical Reviews in Clinical Laboratory Sciences, 57(6), 389–399. https://doi.org/10.1080/10408363.2020.1770685
Sproston, NR, and Ashworth, J. (2018). Role of C-Reactive Protein at Sites of Inflammation and Infection. Fronties in Immunologi.
Thoifah. (2016). Statistika Pendidikan Dan Metode Penelitian Kuantitatif. Madani.
Ullah, W., Thalambedu, N., Haq, S., Saeed, R., Khanal, S., Tariq, S., Roomi, S., Madara, J., Boigon, M., Haas, D. C., & Fischman, D. L. (2020). Predictability of CRP and D-Dimer levels for in-hospital outcomes and mortality of COVID-19. Journal of Community Hospital Internal Medicine Perspectives, 10(5), 402–408. https://doi.org/10.1080/20009666.2020.1798141
Vabret. (2020). Immunology of COVID-19: Current State of the Science. Science Direct.
WHO. (2020). Tes Diagnostik untuk SARS-CoV-2.
Wölfel, R., Corman, V. M., Guggemos, W., Seilmaier, M., Zange, S., Müller, M. A., Niemeyer, D., Jones, T. C., Vollmar, P., Rothe, C., Hoelscher, M., Bleicker, T., Brünink, S., Schneider, J., Ehmann, R., Zwirglmaier, K., Drosten, C., & Wendtner, C. (2020). Virological assessment of hospitalized patients with COVID-2019. Nature, 581(7809), 465–469. https://doi.org/10.1038/s41586-020-2196-x
Yufei, Y., Mingli, L., Xuejiao, L., Xuemei, D., Yiming, J., Qin, Q., Hui, S., & Jie, G. (2020). Utility of the neutrophil-to-lymphocyte ratio and C-reactive protein level for coronavirus disease 2019 (COVID-19). Scandinavian Journal of Clinical and Laboratory Investigation, 80(7), 536–540. https://doi.org/10.1080/00365513.2020.1803587
Zhao, Y., Pan, L., Zhang, Y., Wu, W., He, J., Chen, J., Huang, H. (2020). Detection of SARS-CoV-2 in Different Types of Clinical Specimens. Jurnal Medical Virologi, 93.
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