Efek Pemberian Ekstrak Daun Lidah Buaya (Aloe Vera) Terhadap Penyembuhan Luka Bakar Tikus Putih Jantan (Rattus Novergicus) Galur Wistar
Abstract
Burn injuries are a major cause of morbidity and mortality worldwide, accounting for approximately 180,000 deaths annually. Conventional treatments for burns often cause side effects such as allergic reactions and antibiotic resistance. Aloe vera has been traditionally used as a natural remedy for burns due to its bioactive compounds. This study aims to investigate the effect of aloe vera leaf extract administration on burn wound healing in male Wistar rats (Rattus norvegicus). This experimental research employs a post-test only control group design with 12 rats divided into four groups: negative control, positive control (silver sulfadiazine), and two treatment groups receiving different doses of aloe vera extract. Second-degree burns were induced using a heated iron plate. Parameters observed include wound diameter, healing time, and histopathological analysis of skin tissue. Aloe vera leaf extract contains bioactive compounds such as vitamins A, C, E, flavonoids, saponins, and tannins that play roles in wound healing through anti-inflammatory, antibacterial activities, and collagen synthesis stimulation. This research is expected to provide scientific evidence regarding the effectiveness of aloe vera as a safe, affordable, and accessible natural treatment alternative for burns in the community.
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References
Anderson, L. K., Berman, A. G., & Mehta, D. K. (2020). The role of connective tissue in wound healing: A comprehensive review. Journal of Wound Care, 29(5), 221–229. https://doi.org/10.12968/jowc.2020.29.5.221
Aulia, L., & Pane, Y. S. (2022). Effect of Aloe vera extract in post-burn skin repair in rats. F1000Research, 11, 168. https://doi.org/10.12688/f1000research.79538.2
Chelu, M., Musuc, A. M., Popa, M., & Moreno, J. C. (2023). Aloe vera-based hydrogels for wound healing: Properties and therapeutic effects.
Duarte, M. F., Rodrigues, J. A., & Silva, M. L. (2022). Aloe vera in wound healing: The effectiveness of topical applications. Journal of Herbal Medicine, 35, 70–77. https://doi.org/10.1016/j.hermed.2022.02.007
Iskandar, B., Putri, A. H., Mardani, A. N., Putri, E. M., Tamba, E. C. U., Aulia, F., Rahmadani, S., Handini, W., Wulandari, W., & Utami, Z. R. (2025). Potensi sediaan nanogel dari bahan alami dalam regenerasi jaringan: Strategi baru pengobatan luka bakar. Majalah Farmasetika, 10(5).
Johnson, M., & Lee, R. (2021). A five-year overview of burn incidents and mortality in the United States. Burns, 47(5), 1234–1242. https://doi.org/10.1016/j.burns.2021.01.014
Khan, S., & Haider, Z. (2020). Burn injuries and challenges in medical treatment in developing countries. International Journal of Health and Medical Sciences, 8(4), 295–303. https://doi.org/10.1016/j.ijhms.2020.02.004
Kumar, M., & Mistry, P. (2021). The efficacy of Aloe vera gel in wound healing: A meta-analysis. Phytomedicine, 83, 153428. https://doi.org/10.1016/j.phymed.2021.153428
Malek Hosseini, A., Rostam Khani, M., Abdi, S., Abdi, S., & Sharifi, N. (2024). Comparison of Aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: A clinical trial. BMC Research Notes, 17(1), 1–6. https://doi.org/10.1186/s13104-023-06682-8
O’Loughlin, T. M., Zhao, J., & Li, Z. (2020). Comparative effects of silver sulfadiazine and Aloe vera in the treatment of burn wounds. Journal of Burn Care & Research, 41(4), 887–895. https://doi.org/10.1097/BCR.0000000000001235
Pereira, M. G., Teixeira, G. M., & Oliveira, L. P. (2021). Aloe vera as a wound healing agent: From folklore to modern science. International Journal of Pharmaceutical Sciences and Research, 12(6), 2314–2321. https://doi.org/10.13040/IJPSR.0975-8232.12(6).2314-21
Purnamasari, Y. W., Juniarti, Rahmah, N. A., Ernanda, H., & Sari, W. (2024). Effect of Aloe vera gel and sodium metabisulphite on expression of fibroblast growth factor in incision wound of rats. World’s Veterinary Journal, 14(3), 311–317. https://doi.org/10.54203/scil.2024.wvj37
Saputra, D. (2023). Tinjauan komprehensif tentang luka bakar: Klasifikasi, komplikasi, dan penanganan. Scientific Journal, 2(5), 197–208.
Sari, D., Pramudita, R., & Wibowo, A. (2021). The role of medical infrastructure in burn injury management in Indonesia. Journal of Emergency Medicine, 19(2), 91–98. https://doi.org/10.1016/j.jem.2020.12.003
Singh, M., & Kumar, P. (2019). Efficacy of Aloe vera gel versus silver sulfadiazine in burn wound healing: A randomized controlled trial. Burns, 45(3), 606–612. https://doi.org/10.1016/j.burns.2018.12.020
Smith, J., Patel, R., & Fernando, K. (2022). Global statistics on burn-related mortality: Trends and prevention strategies. World Health Organization Bulletin, 34(1), 10–15. https://doi.org/10.1016/j.who.2021.11.004
Surjadi, A., & Pratama, S. (2023). Challenges in burn care in Indonesia: A survey of hospital facilities and patient outcomes. Asian Journal of Trauma and Burn Care, 5(1), 55–64. https://doi.org/10.1016/j.ajtbc.2022.09.005
Wu, Y., Zheng, X., Mobet, Y., Tian, H., Li, F., Li, H., Xie, L., Deng, Y., Zhu, X., Tang, C., Shao, H., & Liu, S. (2024). Research on the role and mechanism of Aloe vera (L.) Burm.f. in the treatment of burn: Based on network pharmacology analysis and experimental verification. Journal of Holistic Integrative Pharmacy, 5(4), 262–276. https://doi.org/10.1016/j.jhip.2024.11.001
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